Molecular model-building by computer.

Many problems of modern biology are concerned with the detailed relation between biological function and molecular structure. Some of the questions currently being asked will be completely answered only when one has an understanding of the structure of all the molecular components of a biological system and a knowledge of how they interact. There are, of course, a large number of problems in biology into which biologists have some insight but concerning which they cannot yet ask suitable questions in terms of molecular structure. As they see such problems more clearly, however, they invariably find an increasing need for structural information. In our laboratory at the Massachusetts Institute of Technology we have recently started using a